Nk1.1 Antibody / Cd161c
NK-1.1 is commonly used as a mouse NK cell marker. It has also been shown to play a role in NK cell activation, IFN- production, and cytotoxic granule release. It is a type II integral membrane glycoprotein with a C-type lectin domain and is encoded by the Klrb1c/NKR-P1C gene. It is predominantly expressed as a disulfide-linked homodimer on NK cells however; it is also expressed on NK-T cells, a rare population of T lymphocytes. NK1.1 is expressed in some mouse strains, including C57BL/6, FVB/N, and NZB, but not AKR, BALB/c, CBA/J, C3H, DBA/1, DBA/2, NOD, SJL, and 129. Expression of NKR-P1C antigen has been correlated with lysis of tumor cells in vitro and rejection of bone marrow allografts in vivo.
Product Specifications
CAS Number
9007-83-4
Specifications
Flow cytometry: 0.5-1ug/million cells in 0.1ml
UniProt
P27814
Host
Mouse
Reactivity
Mouse
Immunogen
Mouse spleen and bone marrow cells enriched for NK-1+ cells were used as the immunogen for the Nk1.1 antibody.
Clonality
Monoclonal
Isotype
IgG2a κ
Clone
PK136
Applications
FACS
Purity
Protein A/G affinity
Format
Purified
Buffer
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
Reconstitution
Aliquot the Nk1.1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This Nk1.1 antibody is available for research use only.
Storage Conditions
Aliquot the Nk1.1 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05% sodium azide
Applications Notes
Optimal dilution of the Nk1.1 antibody should be determined by the researcher.
Location
Cell Surface
Image Legend
SDS-PAGE analysis of purified, BSA-free Nk1.1 antibody (clone PK136) as confirmation of integrity and purity.
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