FRA2 Antibody / FOSL2
The Fos related gene, Fra-2, was initially molecularly cloned from chicken genomic DNA and shown to represent a new member of the immediate early gene family. The human counterpart of the chicken Fra-2 gene has since been described. Sequence alignment shows that the amino acid sequences conserved among Fra-2, c-Fos, Fra-1 and Fos B are contained in five regions. Region 2, the longest and most highly conserved region, contains the leucine zipper structure and the basic region, suggesting that like Fos, Fra-1 and Fos B, Fra-2 also forms heterodimers with c-Jun that recognize a specific DNA sequence such as the binding site for transcription factor AP-1. Such a model is further supported by the finding that the Fra-2 gene product forms a complex with c-Jun in growth-stimulated cells
Product Specifications
CAS Number
9007-83-4
Specifications
Flow cytometry: 1-2ug/million cells, Immunofluorescence: 1-2 µg/mL
UniProt
P15408
Host
Mouse
Reactivity
Human
Immunogen
Recombinant full-length human FOSL2 protein was used as the immunogen for the FRA2 antibody.
Clonality
Monoclonal
Isotype
IgG1
Clone
PCRP-FOSL2-1B1
Applications
FACS, IF
Purity
Protein A/G affinity
Format
Purified
Buffer
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
Reconstitution
Aliquot the FRA2 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This FRA2 antibody is available for research use only.
Storage Conditions
Aliquot the FRA2 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05% sodium azide
Applications Notes
Optimal dilution of the FRA2 antibody should be determined by the researcher.
Location
Nucleus
Image Legend
FACS staining of PFA-fixed human HeLa cells with FRA2 antibody (blue, clone PCRP-FOSL2-1B1), and isotype control (red) .
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