Bcl-W Antibody / Bcl2L2
This gene encodes a member of the BCL-2 protein family. The proteins of this family form hetero- or homodimers and act as anti- and pro-apoptotic regulators. Expression of this gene in cells has been shown to contribute to reduced cell apoptosis under cytotoxic conditions. Studies of the related gene in mice indicated a role in the survival of NGF- and BDNF-dependent neurons. Mutation and knockout studies of the mouse gene demonstrated an essential role in adult spermatogenesis. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring downstream PABPN1 (poly (A) binding protein, nuclear 1) gene.
Product Specifications
CAS Number
9007-83-4
Specifications
Flow cytometry: 1-2ug/million cells, Immunofluorescence: 1-2 µg/mL
UniProt
Q92843
Host
Mouse
Reactivity
Human
Immunogen
Recombinant human full-length BCL2L2/Bcl-W protein was used as the immunogen for the Bcl-W antibody.
Clonality
Monoclonal
Isotype
IgG2b
Clone
PCRP-BCL2L2-1A4
Applications
FACS, IF
Purity
Protein A/G affinity
Format
Purified
Buffer
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
Reconstitution
Aliquot the Bcl-W antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This Bcl-W antibody is available for research use only.
Storage Conditions
Aliquot the Bcl-W antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05% sodium azide
Applications Notes
Optimal dilution of the Bcl-W antibody should be determined by the researcher.
Location
Cytoplasm
Image Legend
Immunofluorescent staining of PFA-fixed human MCF-7 cells using Bcl-W antibody (green, clone PCRP-BCL2L2-1A4) and phalloidin (red) .
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