MCAM Antibody / CD146 / MUC18
The human MCAM gene maps to chromosome 11q23 and encodes a trans-membrane glycoprotein, also designated Mel-CAM, MUC 18 or CD146, that belongs to the immunoglobulin superfamily and functions as a Ca2+-independent cell adhesion molecule. MCAM expression is restricted to advanced primary and metastatic melanomas and to cell lines of the neuroectodermal lineage, but not normal melanocytes. MCAM is found on 80% of advanced primary human melanomas and correlates well with development of metastatic disease.
Product Specifications
CAS Number
9007-83-4
Specifications
ELISA: 2-4 µg/mL (order BSA-free format for coating)
UniProt
P43121
Host
Mouse
Reactivity
Human
Immunogen
Recombinant human MCAM/CD146 protein was used as the immunogen for the MCAM antibody.
Clonality
Monoclonal
Isotype
IgG2c κ
Clone
MCAM/3179
Applications
ELISA
Purity
Protein A/G affinity
Format
Purified
Buffer
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
Reconstitution
Aliquot the MCAM antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This MCAM antibody is available for research use only.
Storage Conditions
Aliquot the MCAM antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05% sodium azide
Applications Notes
Optimal dilution of the MCAM antibody should be determined by the researcher.
Location
Cell Surface
Image Legend
Documents
Frequently Asked Questions
Explore Other Products
Browse additional items from our catalog
