Tyrosinase-Related Protein-1 Antibody / TRP1 / TYRP1
It reacts with a 75kDa melanocyte-specific gene product, identified as Tyrosinase-related protein-1 (TRP-1) . It is involved in melanin synthesis. TRP1 is present on the melanosomal membranes of melanoma, normal melanocytes and nevi.Recent evidence suggests that TRP-1 is involved in maintaining stability of tyrosinase protein and modulating its catalytic activity. TRP-1 is also involved in maintenance of melanosome ultrastructure and affects melanocyte proliferation and cell death.
Product Specifications
CAS Number
9007-83-4
Specifications
Immunohistochemistry (FFPE) : 5-10 µg/mL
UniProt
P17643
Host
Rabbit
Reactivity
Human
Immunogen
Recombinant human TYRP1 protein was used as the immunogen for the Tyrosinase-Related Protein-1 antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
IHC-P
Purity
Protein A affinity
Format
Purified
Buffer
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
Reconstitution
Aliquot the Tyrosinase-Related Protein-1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This Tyrosinase-Related Protein-1 antibody is available for research use only.
Storage Conditions
Aliquot the Tyrosinase-Related Protein-1 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05% sodium azide
Applications Notes
Optimal dilution of the Tyrosinase-Related Protein-1 antibody should be determined by the researcher.
Location
Cytoplasmic
Image Legend
Frequently Asked Questions
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