CD74 Antibody
CD74 is a type II transmembrane protein which binds to the peptide binding groove of newly synthesized MHC class II alpha/beta heterodimers and prevents their premature association with endogenous polypeptides. CD74 is expressed primarily by antigen presenting cells, such as B-lymphocytes (from before the pre-B cell stage to before the plasma cell stage), macrophages, and monocytes, and many epithelial cells. Anti-CD74 stains predominantly germinal center lymphocytes and B-cell lymphomas, but rarely T-cell lymphomas. Anti-CD74 has been shown to be useful in differentiating atypical fibroxanthoma (-) from malignant fibrous histiocytoma (+) .
Product Specifications
CAS Number
9000-83-3
Specifications
ELISA (order BSA-free format for coating)
UniProt
P044233
Host
Rabbit
Reactivity
Human
Immunogen
SU-DHL-4 lymphoma cells were used as the immunogen for the CD74 antibody.
Clonality
Recombinant Monoclonal
Isotype
IgG κ
Clone
CLIP/7023R
Type
Recombinant
Applications
ELISA
Purity
Protein A/G affinity
Format
Purified
Buffer
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
Reconstitution
Aliquot the CD74 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This CD74 antibody is available for research use only.
Storage Conditions
Aliquot the CD74 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05% sodium azide
Applications Notes
Optimal dilution of the CD74 antibody should be determined by the researcher.
Location
Cell surface, Paranuclear globular
Image Legend
SDS-PAGE analysis of purified, BSA-free CD74 antibody (clone CLIP/7023R) as confirmation of integrity and purity.
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