Recombinant Langerin Antibody / CD207
Langerhans cells (LCs) are a subset of immature dendritic cells (DCs) that specifically localize in the epidermis and other mucosal epithelia. Epidermal LCs possess strong immuno-stimulatory capacity and play a central role in the initiation and regulation of immune responses. Langerin (CD207) is a Ca2+-dependent, C-type lectin domain containing, type II transmembrane protein that induces epidermal LCs to differentiate into Birbeck granules (BG) . BGs are organelles with superimposing and zippering membranes that influence proper class I type antigen presentation to the circulating T cells. Human spleen, lymph node, thymus, liver, lung and heart express Langerin protein.
Product Specifications
CAS Number
9000-83-3
Specifications
ELISA: 2-4 µg/mL (order BSA-free format for coating)
UniProt
Q9UJ71
Host
Mouse
Reactivity
Human
Immunogen
A portion of amino acids 74-213 was used as the immunogen for the recombinant Langerin antibody.
Clonality
Recombinant Monoclonal
Isotype
IgG1 k
Clone
RLGRN/1821
Type
Recombinant
Applications
ELISA
Purity
Protein A/G affinity
Format
Purified
Buffer
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
Reconstitution
Aliquot the recombinant Langerin antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This recombinant Langerin antibody is available for research use only.
Storage Conditions
Aliquot the recombinant Langerin antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05% sodium azide
Applications Notes
Optimal dilution of the recombinant Langerin antibody should be determined by the researcher.
Location
Cell surface and cytoplasmic
Image Legend
SDS-PAGE analysis of purified, BSA-free recombinant Langerin antibody (clone rLGRN/1821) as confirmation of integrity and purity.
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