Pan-HLA Antibody MHC II (DP/DQ/DR)
Reacts with a common epitope of human major histocompatibility (MHC) class II antigens, HLA-DP, -DQ and -DR. Human MHC class II antigens are transmembrane glycoproteins composed of an alpha chain (36kDa) and a beta chain (27kDa) . They are expressed primarily on antigen presenting cells such as B lymphocytes, monocytes, macrophages, and thymic epithelial cells and are also present on activated T lymphocytes. Human MHC class II genes are located in the HLA-D region that encodes at least six alpha and ten beta chain genes. Three loci, DR, DQ and DP, encode the major expressed products of the human class II region. The human MHC class II molecules bind intracellularly processed peptides and present them to T-helper cells. They, therefore, have a critical role in the initiation of the immune response.
Product Specifications
CAS Number
9007-83-4
Specifications
Flow cytometry: 1-2ug/million cells, Immunohistochemistry (FFPE) : 1-2 µg/mL
UniProt
P04440 (HLA-DP) ; P01908; P01909; P01920 (HLA-DQ) ; P01903 (HLA-DR)
Host
Mouse
Reactivity
Human
Immunogen
Priess human B cell line was used as the immunogen for the Pan-HLA antibody.
Clonality
Monoclonal
Isotype
IgG1 k
Clone
HLA-Pan/6663
Applications
FACS, IHC-P
Purity
Protein A/G affinity
Format
Purified
Buffer
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
Reconstitution
Aliquot the Pan-HLA antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This Pan-HLA antibody is available for research use only.
Storage Conditions
Aliquot the Pan-HLA antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05% sodium azide
Applications Notes
Optimal dilution of the Pan-HLA antibody should be determined by the researcher.
Location
Cell Surface
Image Legend
Documents
Explore Other Products
Browse additional items from our catalog