Complement C1q B-Chain Antibody / C1QB
C1q, a subcomponent of the classical complement pathway, is composed of nine subunits that mediate classical complement activation and thereby play an important role in the immune response. Six of these subunits are disulfide-linked dimers of chains A and B, while three of these subunits, designated C1q-A through C1q-C, are disulfide-linked dimers of chain C. Each chain contains an N-terminal collagen-like region and a C-terminal C1q globular domain. The presence of receptors for C1q on effector cells modulates its activity, which may be antibody-dependent or independent. Macrophages are the primary source of C1q, while anti-inflammatory drugs as well as cytokines differentially regulate expression of the mRNA as well as the protein. C1q deficiency is associated with lupus erythematosus and glomerulonephritis.
Product Specifications
CAS Number
9007-83-4
Specifications
Immunohistochemistry (FFPE) : 1-2 µg/mL
UniProt
P02746
Host
Mouse
Reactivity
Human
Immunogen
A portion of amino acids 41-188 was used as the immunogen for the Complement C1q B-Chain antibody.
Clonality
Monoclonal
Isotype
IgG κ
Clone
C1QB/2962
Applications
IHC-P
Purity
Protein A/G affinity
Format
Purified
Buffer
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
Reconstitution
Aliquot the Complement C1q B-Chain antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This Complement C1q B-Chain antibody is available for research use only.
Storage Conditions
Aliquot the Complement C1q B-Chain antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Product Datasheet
https://www.nsjbio.com/tds-pdf/complement-c1q-b-chain-antibody-c1qb-c1qb2962-v8815
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05% sodium azide
Applications Notes
Optimal dilution of the Complement C1q B-Chain antibody should be determined by the researcher.
Location
Cell surface, Cytoplasm
Image Legend
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