SOX10 Antibody
SOX-10 is a sensitive marker of melanoma, including conventional, spindled, and desmoplastic subtypes. It is expressed by metastatic melanomas and nodal capsular nevus in sentinel lymph nodes, but not by other lymph node components such as dendritic cells, which usually express S100 protein. Commonly used melanoma markers, such as anti-HMB-45 and anti-Melan-A, are poorly expressed in desmoplastic melanomas while SOX-10 is moderately to strongly expressed in desmoplastic melanomas. SOX-10 is considered as a very reliable marker for recognizing residual desmoplastic melanomas. In normal tissues, it is expressed in Schwann cells, melanocytes, and myoepithelial cells of salivary, bronchial and mammary glands. SOX-10 expression is also observed in mast cells.
Product Specifications
CAS Number
9007-83-4
Specifications
ELISA (For coating purchase antibody without BSA), Western blot: 1-2 µg/mL
UniProt
P56693
Host
Mouse
Reactivity
Human
Immunogen
A portion of amino acids 115-269 was used as the immunogen for the SOX10 antibody.
Clonality
Monoclonal
Isotype
IgG1 k
Clone
SOX10/992
Applications
ELISA, WB
Purity
Protein A/G affinity
Format
Purified
Buffer
1 mg/ml in 1X PBS; BSA free, sodium azide free
Reconstitution
Aliquot the SOX10 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This SOX10 antibody is available for research use only.
Storage Conditions
Aliquot the SOX10 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
1 mg/mL in 1X PBS; BSA free, sodium azide free
Applications Notes
Optimal dilution of the SOX10 antibody should be determined by the researcher.
Location
Nuclear
Image Legend
Western blot testing of human COLO-38 cell lysate using SOX10 antibody (clone SOX10/992) . Expected molecular weight: 50-58 kDa.
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