CK5 Antibody / Cytokeratin 5 / KRT5
This MAb recognizes a protein of 58kDa, which is identified as Cytokeratin 5 (KRT5) . This type II cytokeratin is specifically expressed in the basal layer of the epidermis with family member KRT14. Antibodies to KRT5 identify basal cells of squamous and glandular epithelia, myoepithelia, and mesothelium. Anti-cytokeratin 5 has been reported useful in the differential diagnosis of metastatic carcinoma in the pleura versus epithelioid mesothelioma. Almost all squamous cell carcinomas, half of transitional carcinomas, and many undifferentiated large cell carcinomas express. Anti-KRT5, along with anti-p63, affords a high sensitivity and specificity for squamous differentiation. Myoepithelial cells of the breast, glandular epithelia, and basal cells of the prostate are labeled with anti-KRT5.
Product Specifications
CAS Number
9007-83-4
Specifications
Immunohistochemistry (FFPE) : 1-2 µg/mL
UniProt
P13647
Host
Mouse
Reactivity
Human
Immunogen
A portion of amino acids 316-590 was used as the immunogen for the CK5 antibody.
Clonality
Monoclonal
Isotype
IgG1 k
Clone
KRT5/6466
Applications
IHC-P
Purity
Protein A/G affinity
Format
Purified
Buffer
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
Reconstitution
Aliquot the CK5 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This CK5 antibody is available for research use only.
Storage Conditions
Aliquot the CK5 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05% sodium azide
Applications Notes
Optimal dilution of the CK5 antibody should be determined by the researcher.
Location
Cytoplasm
Image Legend
Frequently Asked Questions
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