Amyloid Beta Antibody
Proteolytic cleavage of the Amyloid protein precursor (APP) gives rise to the /A4 Amyloid protein. This protein is involved in the formation of neurofibrillary tangles and plaques that characterize the senile plaques of Alzheimer s patients. APLP1 (Amyloid precursor-like protein 1) and APLP2 are structurally similar to APP. Human APLP2 is a membrane-bound sperm protein that contains a region highly homologous to the transmembrane-cytoplasmic domains of APP found in brain plaques of Alzheimer s disease patients.
Product Specifications
CAS Number
9007-83-4
Specifications
Immunofluorescence: 1-2 µg/mL, Flow cytometry: 1-2ug/million cells, Immunohistochemistry (FFPE) : 1-2 µg/mL for 30 minutes at RT
UniProt
P05067
Host
Mouse
Reactivity
Human
Immunogen
A portion of amino acids 578-680 from the human protein was used as the immunogen for the Amyloid Beta antibody.
Clonality
Monoclonal
Isotype
IgG2c κ
Clone
APP/3345
Applications
IF, FACS, IHC-P
Purity
Protein G affinity chromatography
Format
Purified
Buffer
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
Reconstitution
Store the Amyloid Beta antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This Amyloid Beta antibody is available for research use only.
Storage Conditions
Store the Amyloid Beta antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05% sodium azide
Applications Notes
Optimal dilution of the Amyloid Beta antibody should be determined by the researcher.
Location
Membrane
Image Legend
Immunofluorescent staining of PFA-fixed human U-87 MG cells with Amyloid Beta antibody (clone APP/3345, green) and Reddot nuclear stain (red) .
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