Recombinant Podoplanin Antibody
It recognizes a muco-protein of 38-43kDa, which is identified as Podoplanin (PDPN) . It localizes in stromal cells of peripheral lymphoid tissue and thymic epithelial cells. As a regulator of the lymphatic endothelium, podoplanin probably plays a role in maintaining the unique shape of podocytes. It is selectively expressed in lymphatic endothelium as well as lymphoangiomas, Kaposi sarcomas, and in a subset of angiosarcomas with probable lymphatic differentiation. Recent studies have also shown podoplanin to be a highly sensitive and relatively specific marker for epithelioid mesothelioma. Therefore, it can be used in a panel to distinguish mesotheliomas or mesothelial cells from pulmonary carcinomas.
Product Specifications
CAS Number
9000-83-3
Specifications
ELISA (order Ab without BSA for coating), Western blot: 2-4 µg/mL, Immunohistochemistry (FFPE) : 1-2 µg/mL for 30 minutes at RT
UniProt
Q86YL7
Host
Rabbit
Reactivity
Human
Immunogen
A portion of amino acids 1-100 from the human protein was used as the immunogen for the recombinant Podoplanin antibody.
Clonality
Recombinant Monoclonal
Isotype
IgG
Clone
PDPN/4009R
Type
Recombinant
Applications
ELISA, WB, IHC-P
Purity
Protein A affinity chromatography
Format
Purified
Buffer
1 mg/ml in 1X PBS; BSA free, sodium azide free
Reconstitution
Store the recombinant Podoplanin antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This recombinant Podoplanin antibody is available for research use only.
Storage Conditions
Store the recombinant Podoplanin antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
1 mg/mL in 1X PBS; BSA free, sodium azide free
Applications Notes
Optimal dilution of the recombinant Podoplanin antibody should be determined by the researcher.
Location
Cell surface, cytoplasmic
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