Mesothelin Antibody / MSLN
Mesothelin is a 40kDa glycosyl-phosphatidylinositol-anchored glycoprotein cleaved from a 69kDa precursor protein. Mesothelin immunoreactivity is high in cancers of the ovary (serous papillary, endometrioid and undifferentiated) and pancreas, with less frequent staining seen in adenocarcinomas of the endometrium, lung and stomach/esophagus. Mesothelin is one of the most sensitive markers for mesothelioma.
Product Specifications
CAS Number
9007-83-4
Specifications
Immunohistochemistry (FFPE) : 1-2 µg/mL for 30 minutes at RT, Western blot: 2-4 µg/mL
UniProt
Q13421
Host
Mouse
Reactivity
Human
Immunogen
A portion of amino acids 273-407 from the human protein was used as the immunogen for the Mesothelin antibody.
Clonality
Monoclonal
Isotype
IgG2b κ
Clone
MSLN/3385
Applications
IHC-P, WB
Purity
Protein G affinity chromatography
Format
Purified
Buffer
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
Reconstitution
Store the Mesothelin antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This Mesothelin antibody is available for research use only.
Storage Conditions
Store the Mesothelin antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05% sodium azide
Applications Notes
Optimal dilution of the Mesothelin antibody should be determined by the researcher.
Location
Cytoplasmic, cell surface, secreted
Image Legend
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