Myelin PLP Antibody

Proteolipid protein (PLP) is the major myelin protein of the CNS and plays an important role in the formation and maintenance of myelin. PLP may play a role in the compaction and stabilization of myelin sheaths, as well as in oligodendrocyte development and axonal survival. Mutations in PLP gene can lead to dysmyelinating diseases.

Product Specifications

CAS Number

9007-83-4

Specifications

Immunohistochemistry (FFPE) : 1-2 µg/mL for 30 minutes at RT

UniProt

P60201

Host

Mouse

Reactivity

Human

Immunogen

A synthetic peptide from the C terminal region of the human protein was used as the immunogen for the Myelin PLP antibody. The epitope has been mapped to amino acids GRGTKF.

Clonality

Monoclonal

Isotype

IgG2a

Clone

PLP1/4259

Applications

IHC-P

Purity

Protein G affinity chromatography

Format

Purified

Buffer

0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide

Reconstitution

Store the Myelin PLP antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Limitations

This Myelin PLP antibody is available for research use only.

Storage Conditions

Store the Myelin PLP antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .

Formulation

0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05% sodium azide

Applications Notes

Optimal dilution of the Myelin PLP antibody should be determined by the researcher.

Location

Membrane

Image Legend

IHC staining of FFPE human brain with Myelin PLP antibody (clone PLP1/4259) . HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.