P21 (Acetyl Lys161/K163) rabbit pAb
Function: May be the important intermediate by which p53 mediates its role as an inhibitor of cellular proliferation in response to DNA damage. Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression. induction: By p53, mezerein (antileukemic compound) and interferon beta. PTM: Phosphorylation of Thr-145 by Akt or of Ser-146 by PKC impairs binding to PCNA. similarity: Belongs to the CDI family. tissue specificity: Expressed in all adult human tissues, with 5-fold lower levels observed in the brain.
Product Specifications
Background
Synonyms
Cyclin-dependent kinase inhibitor 1 (CDK-interacting protein 1;Melanoma differentiation-associated protein 6;MDA-6;p21)
Gene ID
1026
UniProt
P38936
Cellular Locus
Cytoplasm. Nucleus.
Host
Rabbit
Species Reactivity
Human,Mouse,Rat
Reactivity
Human; Mouse; Rat
Immunogen
Synthesized peptide derived from human p21 (Acetyl Lys161/K163)
Clonality
Polyclonal
Isotype
IgG
Source
Rabbit
Applications
WB, ELISA
Validated Applications
WB,ELISA
Stability
-20°C/1 year
Concentration
1 mg/mL
Dilution
WB 1:1000-2000 ELISA 1:5000-20000
Molecular Weight
21kD
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.
Product Datasheet
https://www.elkbiotech.com/upload/file/Antibodies/pAb/ES20121-1.pdf
Observed Molecular Weight
21 kD
Subcellular Location
Cytoplasm . Nucleus .
Other Product Names
Cyclin-dependent kinase inhibitor 1 (CDK-interacting protein 1; Melanoma differentiation-associated protein 6; MDA-6; p21)
Gene ID (Human)
1026
SwissProt (Human)
P38936
Available Sizes
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