Recombinant PDL1 Antibody
PD-L1 is a checkpoint regulator in immune cells, it is expressed on immune or non-hematopoietic cells. Expression of the protein is seen during pregnancy where it has a role in suppressing the immune system. PD-L1 induces an inhibitory signal in activated T-cells and promotes T-cell apoptosis. It is overexpressed in a number of different cancers where it is believed to play a significant role in the cancers ability to evade the immune system.
Product Specifications
CAS Number
9000-83-3
Specifications
Immunohistochemistry (FFPE) : 1-2 µg/mL for 30 minutes at RT, Western blot: 2-4 µg/mL
UniProt
Q9NZQ7
Host
Mouse
Reactivity
Human
Immunogen
A portion of amino acids 39-191 from the human protein was used as the immunogen for the recombinant PDL1 antibody.
Clonality
Recombinant Monoclonal
Isotype
IgG2a κ
Clone
RPDL1/4773
Type
Recombinant
Applications
IHC-P, WB
Purity
Protein G affinity chromatography
Format
Purified
Buffer
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
Reconstitution
Store the recombinant PDL1 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This recombinant PDL1 antibody is available for research use only.
Storage Conditions
Store the recombinant PDL1 antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05% sodium azide
Applications Notes
Optimal dilution of the recombinant PDL1 antibody should be determined by the researcher.
Location
Cell surface, cytoplasmic
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Frequently Asked Questions
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