Recombinant CD137 Antibody / 4-1BB / TNFRSF9

CD137 belongs to the tumor necrosis factor receptor family and delivers a costimulatory signal to T lymphocytes. It is expressed on activated T cells and binds an inducible ligand that is found on B cells, macrophages and dendritic cells. Interactions between CD137 and its ligand are involved in antigen presentation and the generation of cytotoxic T cells. CD137 antibody may improve cancer treatment, and has been implicated in breast cancer, melanoma and lymphoma.

Product Specifications

CAS Number

9000-83-3

Specifications

Immunohistochemistry (FFPE) : 2-4 µg/mL for 30 minutes at RT

UniProt

Q07011

Host

Mouse

Reactivity

Human

Immunogen

A portion of amino acids 19-188 from the human protein was used as the immunogen for the recombinant CD137 antibody.

Clonality

Recombinant Monoclonal

Isotype

IgG2a κ

Clone

R4-1BB/4603

Type

Recombinant

Applications

IHC-P

Purity

Protein G affinity chromatography

Format

Purified

Buffer

1 mg/ml in 1X PBS; BSA free, sodium azide free

Reconstitution

Store the recombinant CD137 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Limitations

This recombinant CD137 antibody is available for research use only.

Storage Conditions

Store the recombinant CD137 antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .

Formulation

1 mg/mL in 1X PBS; BSA free, sodium azide free

Applications Notes

Optimal dilution of the recombinant CD137 antibody should be determined by the researcher.

Location

Cell surface

Image Legend

IHC staining of FFPE human kidney with recombinant CD137 antibody (clone r4-1BB/4603) . HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.