Endoglin Antibody / CD105
CD105/Endoglin is a Type I membrane glycoprotein located on cell surfaces and is part of the TGF-beta receptor complex. This protein has been found on endothelial cells, activated macrophages, fibroblasts, and smooth-muscle cells. Endoglin has a role in the development of the cardiovascular system and in vascular remodeling. Its expression is regulated during heart development. CD105 is highly expressed in endothelial cells during tumor angiogenesis and inflammation, with weak or negative expression in vascular endothelium of normal tissues. Angiogenesis is a promising prognostic marker in a variety of tumors. Endoglin is a more specific and sensitive marker for tumor angiogenesis than CD31 or CD34, as it labels only newly-formed blood vessels and may serve as a prognostic marker for Prostate Adenocarcinoma, and cancers of the lung, stomach, breast, and brain.
Product Specifications
CAS Number
9007-83-4
Specifications
ELISA: order Ab without BSA for coating, Flow cytometry: 1-2ug/million cells, Immunofluorescence: 2-4 µg/mL
UniProt
P17813
Host
Mouse
Reactivity
Human
Immunogen
A recombinant extracellular fragment from the human protein was used as the immunogen for the Endoglin antibody.
Clonality
Monoclonal
Isotype
IgG1 k
Clone
ENG/1621
Applications
ELISA, FACS, IF
Purity
Protein G affinity chromatography
Format
Purified
Buffer
1 mg/ml in 1X PBS; BSA free, sodium azide free
Reconstitution
Store the Endoglin antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This Endoglin antibody is available for research use only.
Storage Conditions
Store the Endoglin antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
1 mg/mL in 1X PBS; BSA free, sodium azide free
Applications Notes
Optimal dilution of the Endoglin antibody should be determined by the researcher.
Location
Cell surface
Image Legend
Flow cytometry testing of PFA-fixed human HeLa cells with Endoglin antibody (clone ENG/1621) ; Red=isotype control, Blue= Endoglin antibody.
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