OX40 Antibody
This MAb recognizes a protein of 43kDa, identified as OX40, which is also known as CD134. OX40 is a type I integral membrane glycoprotein and member of the tumor necrosis factor/nerve growth factor receptor (TNFR/NGFR) family. It is expressed on activated T lymphocytes, hematopoietic precursor cells and fibroblasts. It functions as a T cell co-stimulatory receptor when bound by OX40 Ligand / TNFSF4 that is expressed by antigen presenting cells. OX40 thereby plays roles in T-cell activation as well as the regulation of differentiation, proliferation or apoptosis of normal and malignant lymphoid cells. OX40 is upregulated at the sites of inflammation, especially in case of multiple sclerosis and psoriatic lesions.
Product Specifications
CAS Number
9007-83-4
Specifications
ELISA: order Ab without BSA for coating, Immunohistochemistry (FFPE) : 1-2 µg/mL for 30 minutes at RT
UniProt
P43489
Host
Mouse
Reactivity
Human
Immunogen
A portion of amino acids 59-205 from the human protein was used as the immunogen for the OX40 antibody.
Clonality
Monoclonal
Isotype
IgG2c κ
Clone
OX40/3427
Applications
ELISA, IHC-P
Purity
Protein G affinity chromatography
Format
Purified
Buffer
1 mg/ml in 1X PBS; BSA free, sodium azide free
Reconstitution
Store the OX40 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This OX40 antibody is available for research use only.
Storage Conditions
Store the OX40 antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
1 mg/mL in 1X PBS; BSA free, sodium azide free
Applications Notes
Optimal dilution of the OX40 antibody should be determined by the researcher.
Location
Cytoplasmic, membranous
Image Legend
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