ACE Antibody / Angiotensin I Converting Enzyme
This gene encodes an enzyme involved in catalyzing the conversion of angiotensin I into a physiologically active peptide angiotensin II. Angiotensin II is a potent vasopressor and aldosterone-stimulating peptide that controls blood pressure and fluid-electrolyte balance. This enzyme plays a key role in the renin-angiotensin system. Many studies have associated the presence or absence of a 287 bp Alu repeat element in this gene with the levels of circulating enzyme or cardiovascular pathophysiologies. Two most abundant alternatively spliced variants of this gene encode two isozymes - the somatic form and the testicular form that are equally active. Multiple additional alternatively spliced variants have been identified but their full length nature has not been determined.
Product Specifications
CAS Number
9007-83-4
Specifications
Western blot: 1-2 µg/mL, ELISA: order Ab without BSA for coating, Immunohistochemistry (FFPE) : 1-2 µg/mL for 30 minutes at RT
UniProt
P12821
Host
Mouse
Reactivity
Human
Immunogen
A portion of amino acids 652-788 from the human protein was used as the immunogen for the ACE antibody.
Clonality
Monoclonal
Isotype
IgG2b κ
Clone
ACE/3765
Applications
WB, ELISA, IHC-P
Purity
Protein G affinity chromatography
Format
Purified
Buffer
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
Reconstitution
Store the ACE antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This ACE antibody is available for research use only.
Storage Conditions
Store the ACE antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05% sodium azide
Applications Notes
Optimal dilution of the ACE antibody should be determined by the researcher.
Location
Cell surface, cytoplasm
Image Legend
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