Recombinant Ferritin Light Chain Antibody / FTL
Mammalian ferritins consist of 24 subunits made up of 2 types of polypeptide chains, ferritin heavy chain and ferritin light chain. Ferritin heavy chains catalyze the first step in iron storage, the oxidation of Fe (II), whereas ferritin light chains promote the nucleation of ferrihydrite, enabling storage of Fe (III) . Light chain ferritin is involved in cataracts by at least two mechanisms, hereditary hyperferritinemia cataract syndrome, in which light chain ferritin is overexpressed, and oxidative stress, an important factor in the development of ageing-related cataracts.
Product Specifications
CAS Number
9000-83-3
Specifications
Western blot: 2-4 µg/mL, Immunohistochemistry (FFPE) : 1-2 µg/mL for 30 minutes at RT
UniProt
P02792
Host
Rabbit
Reactivity
Human
Immunogen
Recombinant full-length human FTL protein was used as the immunogen for the recombinant Ferritin Light Chain antibody.
Clonality
Recombinant Monoclonal
Isotype
IgG
Clone
FTL/3872R
Type
Recombinant
Applications
WB, IHC-P
Purity
Protein A affinity chromatography
Format
Purified
Buffer
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
Reconstitution
Store the recombinant Ferritin Light Chain antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This recombinant Ferritin Light Chain antibody is available for research use only.
Storage Conditions
Store the recombinant Ferritin Light Chain antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05% sodium azide
Applications Notes
Optimal dilution of the recombinant Ferritin Light Chain antibody should be determined by the researcher.
Location
Cytoplasmic
Image Legend
Western blot testing of human kidney lysate with recombinant Ferritin Light Chain antibody (clone FTL/3872R) . Predicted molecular weight: ~20 kDa.
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