Recombinant FTL Antibody / Ferritin Light Chain
Mammalian ferritins consist of 24 subunits made up of 2 types of polypeptide chains, ferritin heavy chain and ferritin light chain. Ferritin heavy chains catalyze the first step in iron storage, the oxidation of Fe (II), whereas ferritin light chains promote the nucleation of ferrihydrite, enabling storage of Fe (III) . Light chain ferritin is involved in cataracts by at least two mechanisms, hereditary hyperferritinemia cataract syndrome, in which light chain ferritin is overexpressed, and oxidative stress, an important factor in the development of ageing-related cataracts.
Product Specifications
CAS Number
9000-83-3
Specifications
Western blot: 1-2 µg/mL, Immunohistochemistry (FFPE) : 1-2 µg/mL for 30 minutes at RT
UniProt
P02792
Host
Mouse
Reactivity
Human
Immunogen
Recombinant full-length human FTL protein was used as the immunogen for the recombinant FTL antibody.
Clonality
Recombinant Monoclonal
Isotype
IgG1 k
Clone
RFTL/1386
Type
Recombinant
Applications
WB, IHC-P
Purity
Protein G affinity chromatography
Format
Purified
Buffer
1 mg/ml in 1X PBS; BSA free, sodium azide free
Reconstitution
Store the recombinant FTL antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This recombinant FTL antibody is available for research use only.
Storage Conditions
Store the recombinant FTL antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
1 mg/mL in 1X PBS; BSA free, sodium azide free
Applications Notes
Optimal dilution of the recombinant FTL antibody should be determined by the researcher.
Location
Cytoplasmic
Image Legend
Western blot testing of human kidney lysate with recombinant FTL antibody. Predicted molecular weight: ~20 kDa.
Documents
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