FTL Antibody / Ferritin Light Chain
Mammalian ferritins consist of 24 subunits made up of 2 types of polypeptide chains, ferritin heavy chain and ferritin light chain. Ferritin heavy chains catalyze the first step in iron storage, the oxidation of Fe (II), whereas ferritin light chains promote the nucleation of ferrihydrite, enabling storage of Fe (III) . Light chain ferritin is involved in cataracts by at least two mechanisms, hereditary hyper-ferritinemia cataract syndrome, in which light chain ferritin is overexpressed, and oxidative stress, an important factor in the development of ageing-related cataracts.
Product Specifications
CAS Number
9007-83-4
Specifications
Immunohistochemistry (FFPE) : 1-2 µg/mL for 30 minutes at RT
UniProt
P02792
Host
Mouse
Reactivity
Human
Immunogen
A portion of amino acids 38-165 from the human protein was used as the immunogen for the FTL antibody.
Clonality
Monoclonal
Isotype
IgG2b κ
Clone
FTL/3100
Applications
IHC-P
Purity
Protein G affinity chromatography
Format
Purified
Buffer
1 mg/ml in 1X PBS; BSA free, sodium azide free
Reconstitution
Store the FTL antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This FTL antibody is available for research use only.
Storage Conditions
Store the FTL antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
1 mg/mL in 1X PBS; BSA free, sodium azide free
Applications Notes
Optimal dilution of the FTL antibody should be determined by the researcher.
Location
Cytoplasmic
Image Legend
Frequently Asked Questions
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