PAI-RBP1 Antibody / SERBP1
PAI-RBP1 / SERBP1 is a membrane-associated protein that localizes to the nucleus, the perinuclear region of the cytoplasm and the plasma membrane. It is believed to play a role in the regulation of mRNA stability, as it specifically binds to the CRS (cyclic nucleotide-responsive sequence) motif of the PAI-1 mRNA and acts to stabilize the mRNA and regulate its expression. In addition, SERBP1 interacts with Mi2-s antiapoptotic action in ovarian cell types. SERBP1 is overexpressed in ovarian cancer, suggesting a possible role in tumorigenesis and tumor metastasis.
Product Specifications
CAS Number
9007-83-4
Specifications
Western blot: 1-2 µg/mL, Immunohistochemistry (FFPE) : 1-2 µg/mL for 30 minutes at RT
UniProt
Q8NC51
Host
Mouse
Reactivity
Human
Immunogen
A portion of amino acids 3-139 from the human protein was used as the immunogen for the PAI-RBP1 antibody.
Clonality
Monoclonal
Isotype
IgG2b κ
Clone
SERBP1/3492
Applications
WB, IHC-P
Purity
Protein G affinity chromatography
Format
Purified
Buffer
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
Reconstitution
Store the PAI-RBP1 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This PAI-RBP1 antibody is available for research use only.
Storage Conditions
Store the PAI-RBP1 antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05% sodium azide
Applications Notes
Optimal dilution of the PAI-RBP1 antibody should be determined by the researcher.
Location
Cytoplasm, nucleus, perinuclear regions
Image Legend
Western blot testing of human 1) K562 and 2) PC-3 cell lysate with PAI-RBP1 antibody. Predicted molecular weight ~45 kDa but observed at 45-60 kDa.
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