SERBP1 Antibody / PAI-RBP1
SERBP1 is a membrane-associated protein that localizes to the nucleus, the perinuclear region of the cytoplasm and the plasma membrane. It is believed to play a role in the regulation of mRNA stability, as it specifically binds to the CRS (cyclic nucleotide-responsive sequence) motif of the PAI-1 mRNA and acts to stabilize the mRNA and regulate its expression. In addition, SERBP1 interacts with Mi2-s antiapoptotic action in ovarian cell types. SERBP1 is overexpressed in ovarian cancer, suggesting a possible role in tumorigenesis and tumor metastasis.
Product Specifications
CAS Number
9007-83-4
Specifications
Western blot: 1-2 µg/mL, Immunohistochemistry (FFPE) : 1-2 µg/mL for 30 minutes at RT
UniProt
Q8NC51
Host
Mouse
Reactivity
Human
Immunogen
A portion of amino acids 3-139 from the human protein was used as the immunogen for the SERBP1 antibody.
Clonality
Monoclonal
Isotype
IgG2b κ
Clone
SERBP1/3494
Applications
WB, IHC-P
Purity
Protein G affinity chromatography
Format
Purified
Buffer
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
Reconstitution
Store the SERBP1 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This SERBP1 antibody is available for research use only.
Storage Conditions
Store the SERBP1 antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05% sodium azide
Applications Notes
Optimal dilution of the SERBP1 antibody should be determined by the researcher.
Location
Cytoplasm, nucleus, perinuclear regions
Image Legend
Western blot testing of human 1) K562 and 2) PC-3 cell lysate with SERBP1 antibody. Predicted molecular weight ~45 kDa but observed at 45-60 kDa.
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