A20 Antibody / TNFAIP3
A20 (also known as TNFAIP3) is a zinc finger protein and inhibits NF-kappa B activation as well as TNF-mediated apoptosis. The protein has both ubiquitin ligase and deubiquitinase activities, is involved in the cytokine-mediated immune and inflammatory responses. A20 is as a tumor suppressor and has been shown to protect MCF-7 breast carcinoma cells from TNF-induced apoptosis. High A20 expression levels were observed in more aggressive breast tumors (ER-negative, progesterone receptor-negative and high histological grade) . These findings strongly suggest that A20 is a key protein involved in tamoxifen resistance.
Product Specifications
CAS Number
9007-83-4
Specifications
Immunohistochemistry (FFPE) : 1-2 µg/mL for 30 minutes at RT
UniProt
P21580
Host
Mouse
Reactivity
Human
Immunogen
A portion of amino acids 241-356 from the human protein was used as the immunogen for the A20 antibody.
Clonality
Monoclonal
Isotype
IgG2c κ
Clone
TNFAIP3/2813
Applications
IHC-P
Purity
Protein G affinity chromatography
Format
Purified
Buffer
1 mg/ml in 1X PBS; BSA free, sodium azide free
Reconstitution
Store the A20 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This A20 antibody is available for research use only.
Storage Conditions
Store the A20 antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Product Datasheet
https://www.nsjbio.com/tds-pdf/a20-antibody-tnfaip3-tnfaip32813-v8384
Formulation
1 mg/mL in 1X PBS; BSA free, sodium azide free
Applications Notes
Optimal dilution of the A20 antibody should be determined by the researcher.
Location
Cytoplasmic, Cell surface and Nuclear
Image Legend
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
Lentiviral human GLYATL1 shRNA (UAS) - Lentiviral human GLYATL1 shRNA (UAS) (25)
