A20 Antibody / TNFAIP3
A20 (also known as TNFAIP3) is a zinc finger protein and inhibits NF-kappa B activation as well as TNF-mediated apoptosis. The protein has both ubiquitin ligase and deubiquitinase activities, is involved in the cytokine-mediated immune and inflammatory responses. A20 is as a tumor suppressor and has been shown to protect MCF-7 breast carcinoma cells from TNF-induced apoptosis. High A20 expression levels were observed in more aggressive breast tumors (ER-negative, progesterone receptor-negative and high histological grade) . These findings strongly suggest that A20 is a key protein involved in tamoxifen resistance.
Product Specifications
CAS Number
9007-83-4
Specifications
Immunohistochemistry (FFPE) : 1-2 µg/mL for 30 minutes at RT
UniProt
P21580
Host
Mouse
Reactivity
Human
Immunogen
A portion of amino acids 241-356 from the human protein was used as the immunogen for the A20 antibody.
Clonality
Monoclonal
Isotype
IgG2c κ
Clone
TNFAIP3/2813
Applications
IHC-P
Purity
Protein G affinity chromatography
Format
Purified
Buffer
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
Reconstitution
Store the A20 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This A20 antibody is available for research use only.
Storage Conditions
Store the A20 antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05% sodium azide
Applications Notes
Optimal dilution of the A20 antibody should be determined by the researcher.
Location
Cytoplasmic, Cell surface and Nuclear
Image Legend
Documents
Frequently Asked Questions
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