LXRB Antibody
The liver X receptors, LXRA (NR1H3) and LXRB (NR1H2) form a subfamily of the nuclear receptor superfamily and are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation. The inducible LXRA is highly expressed in liver, adrenal gland, intestine, adipose tissue, macrophages, lung, and kidney, whereas LXRB is ubiquitously expressed. Ligand-activated LXRs form obligate heterodimers with retinoid X receptors and regulate expression of target genes containing LXR response elements. LXRB can inhibit proliferation and induce apoptosis of cancer cells.
Product Specifications
CAS Number
9007-83-4
Specifications
ELISA: order Ab without BSA for coating
UniProt
P55055
Host
Mouse
Reactivity
Human
Immunogen
Recombinant full-length human NR1H2/LXRB protein was used as the immunogen for the LXRB antibody.
Clonality
Monoclonal
Isotype
IgG2c κ
Clone
LXRB/2731
Applications
ELISA
Purity
Protein G affinity chromatography
Format
Purified
Buffer
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
Reconstitution
Store the LXRB antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This LXRB antibody is available for research use only.
Storage Conditions
Store the LXRB antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05% sodium azide
Applications Notes
Optimal dilution of the LXRB antibody should be determined by the researcher.
Location
Nuclear
Image Legend
SDS-PAGE analysis of purified, BSA-free LXRB antibody (clone LXRB/2731) as confirmation of integrity and purity.
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