CTSD Antibody / Cathepsin D
Cathepsin D is a ubiquitously expressed lysosomal aspartyl protease involved in the normal degradation of proteins. It is synthesized as an inactive 52kDa preprocathepsin D that is cleaved and glycosylated to form a 48kDa procathepsin D and then further cleaved to produce 34kDa and 14kDa subunits (heavy and light chains, respectively) . Cathepsin D exhibits pepsin-like activity and plays a role in protein turnover and in the proteolytic activation of hormones and growth factors. Mutations in this gene play a causal role in neuronal ceroid lipofuscinosis-10 and may be involved in the pathogenesis of several other diseases, including breast cancer and possibly Alzheimer's disease.
Product Specifications
CAS Number
9007-83-4
Specifications
Immunohistochemistry (FFPE) : 0.1-0.2 µg/mL, Western blot: 1-2 µg/mL
UniProt
P07339
Host
Mouse
Reactivity
Human
Immunogen
A recombinant human partial protein (amino acids 104-250) was used as the immunogen of the CTSD antibody.
Clonality
Monoclonal
Isotype
IgG1 k
Clone
CTSD/3275
Applications
IHC-P, WB
Purity
Protein G affinity chromatography
Format
Purified
Buffer
0.2 mg/ml with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
Reconstitution
Store the CTSD antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This CTSD antibody is available for research use only.
Storage Conditions
Store the CTSD antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05% sodium azide
Applications Notes
Optimal dilution of the CTSD antibody should be determined by the researcher.
Location
Cytoplasmic
Image Legend
Western blot testing of human liver and MCF7 cell lysate with CTSD antibody.
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