CD40 Antibody
Upon binding to its ligand CD154, CD40 acts as a costimulatory molecule for the activation of B cells, dendritic cells, monocytes, and other APCs. CD40 plays roles in B cell activation, differentiation, proliferation and Ig isotype switching as well as dendritic cell maturation. FGK4.5 can be used for blocking of CD40/CD154 interaction and forin vitroandin vivoactivation of CD40 expressing APCs. This MAb is shown to indirectly activate natural killer (NK) cells, producing significant antitumor and anti-metastatic effects. Effective in boosting immune responses against infectious agents and can potentially be used to treat chronic autoimmune inflammatory processes.
Product Specifications
UniProt
P27512
Host
Rat
Immunogen
Purified recombinant Mouse CD40 fusion protein was used as the immunogen for the CD40 antibody.
Clonality
Monoclonal
Isotype
IgG2a κ
Applications
Functional Studies, FACS, IF
Format
Purified
Buffer
0.2 mg/ml with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
Reconstitution
Store the CD40 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This CD40 antibody is available for research use only.
Product Datasheet
https://cdn.gentaur.com/products/800/6703004/datasheet/v8350-100ug.pdf
CAS Number
9007-83-4
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
