CD134 Antibody / OX40
CD134 is a type I integral membrane protein. This receptor is expressed on activated CD4+and CD8+T cells and B cells. The CD134 binds to CD134 ligand (CD252) to provide a costimulatory signal that is independent of CD28. CD134 is involved in coordinating CD4 T cell selection, migration and cytokine differentiation in T helper (Th) 1 and Th2 cells. CD134 is also involved in the stimulation of T cells, T dependent humoral response and generation of optimal CD4+ T cell responses in vivo and in vitro. CD134 is expressed on activated CD4+ T lymphocytes, and its ligand, CD134L, is found preferentially on activated B cells. Engagement of CD134 with its ligand, CD134L, delivers a strong costimulatory signal to effector T cells.
Product Specifications
CAS Number
9007-83-4
Specifications
This antibody does not block binding of OX40L, Flow cytometry: 1-2ug/10^6 cells in 0.1ml, Immunofluorescence: 1-2 µg/mL
UniProt
P47741
Host
Rat
Reactivity
Mouse
Immunogen
Purified recombinant mouse OX40 antigen was used as the immunogen for the CD134 antibody.
Clonality
Monoclonal
Isotype
IgG1 κ
Clone
OX-86
Applications
FACS, IF
Purity
Protein G affinity chromatography
Format
Purified
Buffer
0.2 mg/ml with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
Reconstitution
Store the CD134 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This CD134 antibody is available for research use only.
Storage Conditions
Store the CD134 antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05% sodium azide
Applications Notes
Optimal dilution of the CD134 antibody should be determined by the researcher.
Image Legend
SDS-PAGE analysis of purified, BSA-free CD134 antibody (clone OX-86) as confirmation of integrity and purity.
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