PD1 Antibody / PDCD1
PD-1 is expressed on a subset of CD4-CD8-thymocytes, and on activated T and B cells. PD-1 is thought to be involved in lymphocyte clonal selection and peripheral tolerance. The PD-1 ligands, PD-L1 (also known as B7-H1) and PD-L2 (B7-DC), are members of the B7 immunoglobulin superfamily. PD-1 is transiently expressed on CD4 and CD8 thymocytes as well as activated T and B-lymphocytes and myeloid cells. Additionally, Pdcd1 mRNA is expressed in developing B-lymphocytes during the pro-B-cell stage. The RMP1-14 antibody has been reported to block the binding of PD-1 to its ligands (B7-H1 and B7-DC) and to inhibit T cell proliferation and cytokine production co-stimulated by macrophages (but not by dendritic cells and B cells) .</strong>
Product Specifications
CAS Number
9007-83-4
Specifications
UniProt
Q02242
Host
Rat
Reactivity
Mouse
Immunogen
PDCD1 transfected BHK cells were used as the immunogen for the PD1 antibody.
Clonality
Monoclonal
Isotype
IgG2a κ
Clone
RMP1-14
Applications
ELISA, Neutralization, FACS, IF
Purity
Protein G affinity chromatography
Format
Purified
Buffer
0.2 mg/ml with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
Reconstitution
Store the PD1 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This PD1 antibody is available for research use only.
Storage Conditions
Store the PD1 antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05% sodium azide
Applications Notes
Optimal dilution of the PD1 antibody should be determined by the researcher.
Image Legend
SDS-PAGE analysis of purified, BSA-free PD1 antibody (clone RMP1-14) as confirmation of integrity and purity.
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