HPV-16 E6 + HPV-18 E6 Antibody Cocktail
Human papilloma viruses (HPVs) can be classified as either high risk or low risk according to their association with cancer. HPV16 and HPV18 are the most common of the high risk group while HPV6 and HPV11 are among the low risk types. Approximately 90% of cervical cancers contain HPV DNA of the high risk types. Mutational analysis has shown that the E6 and E7 genes of the high risk HPVs are necessary and sufficient for HPV transforming function. The specific interactions of the E6 and E7 proteins with p53 and pRB, respectively, correlate with HPV high and low risk classifications. The high risk HPV E7 proteins bind to pRB with a higher affinity than do the low risk HPV proteins, and only the high risk HPV E6 proteins form detectable complexes with p53 in vitro.
Product Specifications
CAS Number
9007-83-4
Specifications
Immunohistochemistry (FFPE) : 1-2 µg/mL
Host
Mouse
Reactivity
HPV-16
Immunogen
HPV18 E6-β-galactosidase fusion protein was used as the immunogen for this HPV-16 E6 + HPV-18 E6 antibody cocktail.
Clonality
Monoclonal
Isotype
IgG1 k
Clone
HPV16/1295 + HPV18/1297
Applications
IHC-P
Purity
Protein G affinity chromatography
Format
Purified
Buffer
0.2 mg/ml with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
Reconstitution
Store the HPV-16 E6 + HPV-18 E6 antibody cocktail at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This HPV-16 E6 + HPV-18 E6 antibody cocktail is available for research use only.
Storage Conditions
Store the HPV-16 E6 + HPV-18 E6 antibody cocktail at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05% sodium azide
Applications Notes
Optimal dilution of the HPV-16 E6 + HPV-18 E6 antibody cocktail should be determined by the researcher.
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