µ-Conotoxin KIIIA
Product Specifications
UNSPSC Description
μ-Conotoxin KIIIA is an analgesic μ-conotoxin that can be isolated from Conus kinoshitai. μ-Conotoxin KIIIA blocks mammalian neuronal voltage-gated sodium channels (VGSCs) (Nav1.2).μ-Conotoxin KIIIA can be used for research of pain[1][2].
Target Antigen
Sodium Channel
Type
Peptides
Related Pathways
Membrane Transporter/Ion Channel
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Solubility
10 mM in DMSO
Smiles
O=C([C@@H](N)CSSC[C@H](NC1=O)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H]2CCCNC(N)=N)=O)CO)=O)CC3=CNC=N3)=O)CC(O)=O)=O)CCCNC(N)=N)=O)N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H]1CC4=CNC5=CC=CC=C45)=O)CCCCN)=O)CO)=O)CO)=O)CSSC[C@H](NC6=O)C(N)=O)=O)CC(N)=O)=O)CSSC[C@@H]6NC2=O
Molecular Weight
1884.16
References & Citations
[1]Khoo KK,et al. Structure of the analgesic mu-conotoxin KIIIA and effects on the structure and function of disulfide deletion. Biochemistry. 2009 Feb 17;48(6):1210-9.|[2]Pan X, Li Z, et al. Molecular basis for pore blockade of human Na+ channel Nav1.2 by the μ-conotoxin KIIIA. Science. 2019 Mar 22;363(6433):1309-1313.
Shipping Conditions
Room temperature
Clinical Information
No Development Reported
CAS Number
884469-67-4
Curated Selection
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