µ-Conotoxin KIIIA

μ-Conotoxin KIIIA is an analgesic μ-conotoxin that can be isolated from Conus kinoshitai. μ-Conotoxin KIIIA blocks mammalian neuronal voltage-gated sodium channels (VGSCs) (Nav1.2).μ-Conotoxin KIIIA can be used for research of pain[1][2].

O=C([C@@H](N)CSSC[C@H](NC1=O)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H]2CCCNC(N)=N)=O)CO)=O)CC3=CNC=N3)=O)CC(O)=O)=O)CCCNC(N)=N)=O)N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H]1CC4=CNC5=CC=CC=C45)=O)CCCCN)=O)CO)=O)CO)=O)CSSC[C@H](NC6=O)C(N)=O)=O)CC(N)=O)=O)CSSC[C@@H]6NC2=O

[1]Khoo KK,et al. Structure of the analgesic mu-conotoxin KIIIA and effects on the structure and function of disulfide deletion. Biochemistry. 2009 Feb 17;48(6):1210-9.|[2]Pan X, Li Z, et al. Molecular basis for pore blockade of human Na+ channel Nav1.2 by the μ-conotoxin KIIIA. Science. 2019 Mar 22;363(6433):1309-1313.