Herpes Virus 8 Antibody

HHV 8 encodes a latent nuclear antigen (LNA), which is the product of the viral gene orf 73. LNA is capable of forming a complex with retinoblastoma susceptibility gene product, which may be related to its oncogenic activity. HHV8 is associated with three different diseases observed in AIDS patients; kaposi's sarcoma, primary effusion lymphoma (which is a rare type of non-Hodgkin lymphoma affecting the body cavities) and multicentric Castleman's disease. HHV 8 is the likely etiological agent of Kaposis sarcoma.

Product Specifications

CAS Number

9007-83-4

Specifications

ELISA (order BSA-free format for coating), Immunohistochemistry (FFPE) : 1-2 µg/mL

Host

Mouse

Reactivity

HSV-1

Immunogen

Recombinant protein corresponding to the latent nuclear antigen 1 molecule of HHV8 was used as the immunogen for this Herpes Virus 8 antibody.

Clonality

Monoclonal

Isotype

IgG1 k

Clone

HHV8/3606

Applications

ELISA, IHC-P

Purity

Protein G affinity chromatography

Format

Purified

Buffer

0.2 mg/ml with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide

Reconstitution

Store the Herpes Virus 8 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Limitations

This Herpes Virus 8 antibody is available for research use only.

Storage Conditions

Store the Herpes Virus 8 antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .

Formulation

0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05% sodium azide

Applications Notes

Optimal dilution of the Herpes Virus 8 antibody should be determined by the researcher.

Image Legend

IHC staining of FFPE Kaposiâ€™s sarcoma with Herpes Virus 8 antibody (clone HHV8/3606) . HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.