VEGFR2 Antibody / VEGF Receptor 2 / KDR
This MAb is specific to Mouse VEGFR2/FLK-1/CD309 and does not cross-react with FLK-2. VEGFR2 is a type I transmembrane glycoprotein. It is a member of the CSF-1/PDGF receptor family of type III tyrosine kinase receptors. Endothelial cells, embryonic tissues, and megakaryocytes mainly express VEGFR2. It plays an important role in the regulation of angiogenesis, vasculogenesis, and vascular permeability. The ligands of VEGFR2 include VEGF-A, VEGF-C, VEGF-D, and VEGF splice isoforms. Ligation of VEGFR2 with its ligands results in the receptor dimerization and auto-phosphorylation, stimulating endothelial cell proliferation and migration.
Product Specifications
CAS Number
9007-83-4
Specifications
Western blot (Non-reducing) : 2-5 µg/mL, Blocks binding of VEGF to VEGF-R2, Inhibits VEGF-induced signalingformat), Blocks tumor growth in mice
UniProt
P35918
Host
Rat
Reactivity
Mouse
Immunogen
Recombinant full-length Mouse VEGFR2 protein was used as the immunogen for this VEGFR2 antibody.
Clonality
Monoclonal
Isotype
IgG1 κ
Clone
DC101
Applications
WB, Neutralizing, Blocking, Inhibition
Purity
Protein G affinity chromatography
Format
Purified
Buffer
1 mg/ml in 1X PBS; BSA free, sodium azide free
Reconstitution
Store the VEGFR2 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This VEGFR2 antibody is available for research use only.
Storage Conditions
Store the VEGFR2 antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
1 mg/mL in 1X PBS; BSA free, sodium azide free
Applications Notes
Optimal dilution of the VEGFR2 antibody should be determined by the researcher.
Image Legend
SDS-PAGE analysis of purified, BSA-free VEGFR2 antibody (clone DC101) as confirmation of integrity and purity.
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