NKX3.1 Antibody
NKX3.1 is a prostate specific gene encoding a transcription factor that plays an important role in normal prostate development and carcinogenesis. It is a prostatic tumor suppressor gene located on chromosome 8p21.2, which frequently undergoes a loss of heterozygosity. NKX3.1 expression is highly restricted in prostate epithelial cells and therefore can be used as a diagnostic biomarker for prostate cancer and other metastatic lesions of prostatic origin. Furthermore, NKX3.1 shows better sensitivity than Prostate Specific Antigen (PSA) for identifying metastatic prostatic adenocarcinoma. This suggests that immunohistochemical staining of NKX3.1, along with other prostate-restricted markers, may be valuable for the definitive determination of prostatic origin in poorly differentiated metastatic carcinomas.
Product Specifications
CAS Number
9007-83-4
Specifications
ELISA (order BSA-free format for coating), Immunohistochemistry (FFPE) : 1-2 µg/mL
UniProt
Q99801
Host
Mouse
Reactivity
Human
Immunogen
A recombinant human partial protein (amino acids 92-224) was used as the immunogen for the NKX3.1 antibody.
Clonality
Monoclonal
Isotype
IgG2b κ
Clone
NKX3.1/3348
Applications
ELISA, IHC-P
Purity
Protein G affinity chromatography
Format
Purified
Buffer
0.2 mg/ml with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
Reconstitution
Store the NKX3.1 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This NKX3.1 antibody is available for research use only.
Storage Conditions
Store the NKX3.1 antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05% sodium azide
Applications Notes
Optimal dilution of the NKX3.1 antibody should be determined by the researcher.
Location
Nuclear
Image Legend
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