Aurora B Antibody / AURKB
Recognizes a protein of 39kDa, which is identified as Aurora B. The serine/threonine protein kinase aurora B (Aurora B) is a chromosomal passenger protein critical for accurate chromosome segregation, cytokinesis, protein localization to the centromere and kinetochore, correct microtubule-kinetochore attachment, and regulation of the mitotic checkpoint. Aurora B forms a tight complex with inner centrosome protein and survivin. Inactivation of any of these proteins causes similar defects in chromosome segregation. A significant overexpression of Aurora B has been found in a variety of human tumors including non-small cell lung carcinoma, astrocytoma, seminoma and carcinomas of the colon, prostate, endometrium and thyroid. The expression level of Aurora B is associated with cell proliferation and prognosis in these tumors.
Product Specifications
CAS Number
9007-83-4
Specifications
Immunohistochemistry (FFPE) : 1-2 µg/mL
UniProt
Q96GD4
Host
Mouse
Reactivity
Human
Immunogen
A recombinant human protein fragment (amino acids 89-251) was used as the immunogen for this Aurora B antibody.
Clonality
Monoclonal
Isotype
IgG1 k
Clone
AURKB/1845
Applications
IHC-P
Purity
Protein G affinity chromatography
Format
Purified
Buffer
0.2 mg/ml with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
Reconstitution
Store the Aurora B antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This Aurora B antibody is available for research use only.
Storage Conditions
Store the Aurora B antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05% sodium azide
Applications Notes
Optimal dilution of the Aurora B antibody should be determined by the researcher.
Location
Nuclear, cytoplasmic
Image Legend
Frequently Asked Questions
Explore Other Products
Browse additional items from our catalog
Tissue, Total RNA, Human Adult Normal, Tongue, BioGenomicsTM
SSA1 (Tripartite Motif-containing 21, 52kD Ribonucleoprotein Autoantigen Ro/SS-A, 52kD Ro Protein, RING Finger Protein 81, RNF81, Ro(SS-A), RO52, Sjoegren Syndrome Type A Antigen, SSA, SS-A, TRIM21, Tripartite Motif-containing Protein 21) (MaxLight 550)
SSA1 (Tripartite Motif-containing 21, 52kD Ribonucleoprotein Autoantigen Ro/SS-A, 52kD Ro Protein, RING Finger Protein 81, RNF81, Ro(SS-A), RO52, Sjoegren Syndrome Type A Antigen, SSA, SS-A, TRIM21, Tripartite Motif-containing Protein 21) (MaxLight 550)