CD4 Antibody
Recognizes a protein of 55kDa, identified as CD4. It is a membrane glycoprotein of T lymphocytes that interacts with major histocompatibility complex class II antigens and is also a receptor for the human immunodeficiency virus. This protein is expressed not only in T lymphocytes, but also in B cells, macrophages, and granulocytes. It is also expressed in specific regions of the brain. The protein functions to initiate or augment the early phase of T-cell activation, and may function as an important mediator of indirect neuronal damage in infectious and immune-mediated diseases of the central nervous system. Multiple alternatively spliced transcript variants encoding different isoforms have been identified.
Product Specifications
CAS Number
9007-83-4
Specifications
Functional Studies (order BSA/azide-free format), Flow cytometry: 1-2ug/10^6 cells in 0.1ml, Immunofluorescence: 1-2 µg/mL
UniProt
P06332
Host
Mouse
Reactivity
Human
Immunogen
Human peripheral lymphocytes were used as the immunogen for the CD4 antibody.
Clonality
Monoclonal
Isotype
IgG2a κ
Clone
RIV7
Applications
Functional Studies, FACS, IF
Purity
Protein G affinity chromatography
Format
Purified
Buffer
0.2 mg/ml with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
Reconstitution
Store the CD4 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This CD4 antibody is available for research use only.
Storage Conditions
Store the CD4 antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05% sodium azide
Applications Notes
Optimal dilution of the CD4 antibody should be determined by the researcher.
Location
Cell surface
Image Legend
Flow cytometry staining of lymphocyte gated human PBM cells with CD4 antibody; Gray=isotype control, Red= CD4 antibody.
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