Cyclin E1 Antibody / CCNE1
Cyclin E belongs to the highly conserved cyclin family, whose members exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. Cyclins function as regulators of CDK kinases. Cyclin E forms a complex with and functions as a regulatory subunit of CDK2, whose activity is required for cell cycle G1/S transition. Cyclin E accumulates at the G1-S phase boundary and is degraded as cells progress through S phase. Cyclin E overexpression has been observed in many tumors, which results in chromosome instability, and thus may contribute to tumorigenesis.
Product Specifications
CAS Number
9007-83-4
Specifications
ELISA (order BSA-free format for coating)
UniProt
P24864
Host
Mouse
Reactivity
Human
Immunogen
A recombinant human partial protein (amino acids 10-176) was used as the immunogen for this Cyclin E1 antibody.
Clonality
Monoclonal
Isotype
IgG
Clone
CCNE1/2587
Applications
ELISA
Purity
Protein G affinity chromatography
Format
Purified
Buffer
0.2 mg/ml with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
Reconstitution
Store the Cyclin E1 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This Cyclin E1 antibody is available for research use only.
Storage Conditions
Store the Cyclin E1 antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05% sodium azide
Applications Notes
Optimal dilution of the Cyclin E1 antibody should be determined by the researcher.
Image Legend
SDS-PAGE analysis of purified, BSA-free Cyclin E1 antibody (clone CCNE1/2587) as confirmation of integrity and purity.
Frequently Asked Questions
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