CD137L Antibody / 4-1BBL / TNFSF9
TNFSF9 / 4-1BBL is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This transmembrane cytokine is a bidirectional signal transducer that acts as a ligand for TNFRSF9 / 4-1BB, which is a costimulatory receptor molecule in T lymphocytes. This cytokine and its receptor are involved in the antigen presentation process and in the generation of cytotoxic T cells. The receptor TNFRSF9 / 4-1BB is absent from resting T lymphocytes but rapidly expressed upon antigenic stimulation. It has been shown to reactivate anergic T lymphocytes in addition to promoting T lymphocyte proliferation. This cytokine is required for the optimal CD8 responses in CD8 T cells. This cytokine is expressed in carcinoma cell lines, and is thought to be involved in T cell-tumor cell interaction.
Product Specifications
CAS Number
9007-83-4
Specifications
Flow cytometry: 1-2ug/10^6 cells in 0.1ml, Immunohistochemistry (FFPE) : 1-2 µg/mL
UniProt
P41273
Host
Mouse
Reactivity
Human
Immunogen
A recombinant full-length human CD137L protein was used as the immunogen for the CD137L antibody.
Clonality
Monoclonal
Isotype
IgG2a κ
Clone
CD137L/1547
Applications
FACS, IHC-P
Purity
Protein G affinity chromatography
Format
Purified
Buffer
0.2 mg/ml with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
Reconstitution
Store the CD137L antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This CD137L antibody is available for research use only.
Storage Conditions
Store the CD137L antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05% sodium azide
Applications Notes
Optimal dilution of the CD137L antibody should be determined by the researcher.
Location
Cell surface, cytoplasmic
Image Legend
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