PDL2 Antibody / Programmed death ligand 2 / CD273
Recognizes a protein of about 31kDa, which is identified as PD-L2 (same as PDCD1LG2) . Engagement of CD28 by B7-1 (CD80) or B7-2 (CD86) in the presence of antigen promotes T cell proliferation, cytokine production, differentiation of effector T cells and the induction of Bcl-x, a promoter of T cell survival. Conversely, engagement of CTLA4 by B7-1 or B7-2 may inhibit proliferation and IL-2 production. PD-L2 does not bind CD28, cytotoxic T lymphocyte A4 or ICOS (inducible co-stimulator) . The constitutive expression of PD-L1 and PD-L2 on parenchymal cells of heart, lung and kidney suggests that the Pdcd-1-Pdcd-L system could provide unique negative signaling to help prevent autoimmune disease.
Product Specifications
CAS Number
9007-83-4
Specifications
Flow cytometry: 1-2ug/10^6 cells in 0.1ml
UniProt
Q9Q51
Host
Mouse
Reactivity
Human
Immunogen
A recombinant fragment of human PD-L2 protein within amino acids 27-220 was used as the immunogen for the PDL2 antibody.
Clonality
Monoclonal
Isotype
IgG1 k
Clone
PDL2/1850
Applications
FACS
Purity
Protein G affinity chromatography
Format
Purified
Buffer
0.2 mg/ml with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
Reconstitution
Store the PDL2 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This PDL2 antibody is available for research use only.
Storage Conditions
Store the PDL2 antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05% sodium azide
Applications Notes
Optimal dilution of the PDL2 antibody should be determined by the researcher.
Image Legend
Flow cytometry testing of human Jurkat cells with PDL2 antibody; Red=isotype control, Blue= PD-L2 antibody.
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