B7-H4 Antibody / VTCN1
T cell activation and immune function are regulated by the innate immune system through positive and negative costimulatory proteins. One such protein, B7-H4 (B7-homolog 4), belongs to the B7 immunoglobulin superfamily of ligand-lymphocyte interacting proteins. Expressed primarily on the membrane of lymphoid cells, B7-H4 is an immuno-inhibitory protein that interacts with receptors on the surface of T lymphocytes, thus mediating cellular and humoral immune responses. Overexpression of the B7-H4 protein is associated with certain malignancies, including ovarian and breast cancer, as its interaction with T cells suppresses tumor-associated immunity. Current research suggests that, similar to Mucin 16 (CA-125), B7-H4 may be a useful biomarker for the early detection of ovarian cancer.
Product Specifications
CAS Number
9007-83-4
Specifications
UniProt
Q7Z7D3
Host
Mouse
Reactivity
Human
Immunogen
A recombinant human partial protein was used as the immunogen for this B7-H4 antibody.
Clonality
Monoclonal
Isotype
IgG2a κ
Clone
B7H4/1788
Applications
ELISA, FACS, IF, WB, IHC-P
Purity
Protein G affinity chromatography
Format
Purified
Buffer
0.2 mg/ml with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
Reconstitution
Store the B7-H4 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This B7-H4 antibody is available for research use only.
Storage Conditions
Store the B7-H4 antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05% sodium azide
Applications Notes
Optimal dilution of the B7-H4 antibody should be determined by the researcher.
Location
Cell surface, cytoplasmic
Image Legend
Immunofluorescent staining of fixed human SK-BR-3 cells with B7-H4 antibody (clone B7H4/1788, green) and Reddot nuclear stain (red) .
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