Tyrosinase-Related Protein-1 Antibody / TRP1 / TYRP1
It reacts with a 75kDa melanocyte-specific gene product, identified as Tyrosinase-related protein-1 (TRP-1) . It is involved in melanin synthesis. TRP1 is present on the melanosomal membranes of melanoma, normal melanocytes and nevi.Recent evidence suggests that TRP-1 is involved in maintaining stability of tyrosinase protein and modulating its catalytic activity. TRP-1 is also involved in maintenance of melanosome ultrastructure and affects melanocyte proliferation and cell death.
Product Specifications
CAS Number
9007-83-4
Specifications
ELISA (order BSA-free format for coating), Immunohistochemistry (FFPE) : 1-2 µg/mL
UniProt
P17643
Host
Mouse
Reactivity
Human
Immunogen
A recombinant human partial protein (amino acids 257-377) was used as the immunogen for this Tyrosinase-Related Protein-1 antibody.
Clonality
Monoclonal
Isotype
IgG2b κ
Clone
TYRP1/3280
Applications
ELISA, IHC-P
Purity
Protein G affinity chromatography
Format
Purified
Buffer
0.2 mg/ml with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
Reconstitution
Store the Tyrosinase-Related Protein-1 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This Tyrosinase-Related Protein-1 antibody is available for research use only.
Storage Conditions
Store the Tyrosinase-Related Protein-1 antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05% sodium azide
Applications Notes
Optimal dilution of the Tyrosinase-Related Protein-1 antibody should be determined by the researcher.
Location
Cytoplasmic
Image Legend
Frequently Asked Questions
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