What is the catalog number for Recombinant Thymidylate Synthase Antibody?

The catalog number for Recombinant Thymidylate Synthase Antibody is V8144SAF-100UG.

What sizes are available for Recombinant Thymidylate Synthase Antibody?

Recombinant Thymidylate Synthase Antibody is available in the following size(s): 100 µg.

Is Recombinant Thymidylate Synthase Antibody in stock?

Recombinant Thymidylate Synthase Antibody is currently made to order / not held in immediate stock. Contact us for lead time.

Recombinant Thymidylate Synthase Antibody

It recognizes a protein of 36kDa, identified as Thymidylate Synthase (TS) (EC 2.1.1.45) . It converts deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP), which is essential for DNA biosynthesis. TS is also a critical target for the fluoropyrimidines, an important group of antineoplastic drugs that are widely used in the treatment of solid tumors. Both 5-FU and fluorodeoxyuridine are converted in tumor cells to FdUMP which inactivates TS by formation of a ternary covalent complex in the presence of the folate cofactor 5,10-methylenetetrahydrofolate. Expression of TS protein has been reported to associate with response to 5-fluorouracil (5-FU) in human colorectal, gastric, head and neck, and breast carcinomas.

Product Specifications

CAS Number

9000-83-3

Specifications

Flow cytometry: 1-2ug/million cells in 0.1ml, Immunofluorescence: 1-2 µg/mL

UniProt

P04818

Host

Mouse

Reactivity

Human

Immunogen

A recombinant human partial protein (amino acids 60-174) was used as the immunogen for the recombinant Thymidylate Synthase antibody.

Clonality

Recombinant Monoclonal

Isotype

IgG1 k

Clone

RTYMS/1884

Type

Recombinant

Applications

FACS, IF

Purity

Protein G affinity chromatography

Format

Purified

Buffer

1 mg/ml in 1X PBS; BSA free, sodium azide free

Reconstitution

Store the recombinant Thymidylate Synthase antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Limitations

This recombinant Thymidylate Synthase antibody is available for research use only.

Storage Conditions

Store the recombinant Thymidylate Synthase antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .

Formulation

1 mg/mL in 1X PBS; BSA free, sodium azide free

Applications Notes

Optimal dilution of the recombinant Thymidylate Synthase antibody should be determined by the researcher.

Location

Nuclear, cytoplasmic

Image Legend

Flow cytometry testing of PFA-fixed human MOLT4 cells with recombinant Thymidylate Synthase antibody (clone rTYMS/1884) ; Red=isotype control, Blue= recombinant Thymidylate Synthase antibody.