SDHB Antibody
Succinate dehydrogenase (SDH) is Complex II in the mitochondria, vital for mitochondrial electron transport, as well as Krebs cycle function.Four subunits comprise the SDH protein complex: a flavochrome subunit (SDHA), an iron-sulfur protein (SDHB) and two membrane-bound subunits (SDHC and SDHD) anchored to the inner mitochondrial membrane. The SDH complex functions as a tumor suppressor. Loss of any subunit proteins lead to destabilization of the complex and tumor formation.Antibody to SDHB is helpful in the identification of phaeochromocytomas, paragangliomas and GIST.
Product Specifications
CAS Number
9007-83-4
Specifications
Western blot: 2-4 µg/mL
UniProt
P21912
Host
Mouse
Reactivity
Human
Immunogen
A recombinant human partial protein (amino acids 165-273) were used as the immunogen for this SDHB antibody.
Clonality
Monoclonal
Isotype
IgG2b κ
Clone
SDHB/2382
Applications
WB
Purity
Protein G affinity chromatography
Format
Purified
Buffer
1 mg/ml in 1X PBS; BSA free, sodium azide free
Reconstitution
Store the SDHB antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This SDHB antibody is available for research use only.
Storage Conditions
Store the SDHB antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Product Datasheet
https://www.nsjbio.com/tds-pdf/sdhb-antibody-sdhb2382-v8073
Formulation
1 mg/mL in 1X PBS; BSA free, sodium azide free
Applications Notes
Optimal dilution of the SDHB antibody should be determined by the researcher.
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