Recombinant PD-L1 Antibody / B7-H1 / CD274
PD-L1 is a checkpoint regulator in immune cells, it is expressed on immune or non-hematopoietic cells. Expression of the protein is seen during pregnancy where it has a role in suppressing the immune system. PD-L1 induces an inhibitory signal in activated T-cells and promotes T-cell apoptosis. It is overexpressed in a number of different cancers where it is believed to play a significant role in the cancer’s ability to evade the immune system.
Product Specifications
CAS Number
9000-83-3
Specifications
Immunohistochemistry (FFPE) : 1-2 µg/mL for 30 min at RT
UniProt
Q9NZQ7
Host
Mouse
Reactivity
Human
Immunogen
A portion of amino acids 39-191 from the human protein was used as the immunogen for this recombinant PD-L1 antibody.
Clonality
Recombinant Monoclonal
Isotype
IgG κ
Clone
PDL1/4451R
Type
Recombinant
Applications
IHC-P
Purity
Protein A affinity chromatography
Format
Purified
Buffer
1 mg/ml in 1X PBS; BSA free, sodium azide free
Reconstitution
Store the recombinant PD-L1 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This recombinant PD-L1 antibody is available for research use only.
Storage Conditions
Store the recombinant PD-L1 antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
1 mg/mL in 1X PBS; BSA free, sodium azide free
Applications Notes
Optimal dilution of the recombinant PD-L1 antibody should be determined by the researcher.
Location
Cell surface, cytoplasm
Image Legend
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