NME1 Antibody / NM23
The nm23 gene, a potential suppressor of metastasis, was originally identified by differential hybridization between two murine melanoma sub-lines, one with a high and the second with a low metastatic capacity. Highly metastatic sub-lines exhibit much lower levels of nm23 than less metastatic cells. Based on sequence analysis, nm23 appears highly related to nucleotide diphosphate kinases (NDP-K) . In humans, NDP kinase A and B are identical to two isotypes of human nm23 homologs, namely nm23-H1 and H2, respectively. nm23-H2 is identical in sequence to PuF, a transcription factor that binds to nuclease hypersensitive elements at positions 142 to 115 of the human C-Myc promotor.
Product Specifications
CAS Number
9007-83-4
Specifications
Western blot: 1-2 µg/mL
UniProt
P15531
Host
Mouse
Reactivity
Human
Immunogen
A recombinant full-length human NME1 protein was used as the immunogen for this NME1 antibody.
Clonality
Monoclonal
Isotype
IgG2a κ
Clone
CPTC-NME1-2
Applications
WB
Purity
Protein G affinity chromatography
Format
Purified
Buffer
1 mg/ml in 1X PBS; BSA free, sodium azide free
Reconstitution
Store the NME1 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This NME1 antibody is available for research use only.
Storage Conditions
Store the NME1 antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
1 mg/mL in 1X PBS; BSA free, sodium azide free
Applications Notes
Optimal dilution of the NME1 antibody should be determined by the researcher.
Image Legend
Western blot testing of human HeLa cell lysate with NME1 antibody. Predicted molecular weight ~17 kDa.
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